OVERCOMING RESISTANCE TO MULTIVARIATE ANALYSIS OVER TIME

Overcoming resistance to new food products.

Selling new food products is seldom easy. Of those conceived by the food industry in any year the proportion which are finally found acceptable by the public in terms of the only true criteria of success, namely continuous purchase, is relatively small. But when we turn to products conceived and marketed under the auspices of the international agencies and of the philanthropic bodies of the wor...

Overcoming HIV-1 resistance to RNA interference.

RNAi refers to the sequence-specific degradation of RNA that follows the cellular introduction of homologous short interfering (si) RNA. RNAi has emerged as a powerful tool to probe the function of genes of known sequence in vitro and in vivo. Advances in vector design permit the effective expression of siRNA in human cells. Numerous recent investigations have described the ability of RNAi to d...

Overcoming resistance to MAPK pathway inhibitors.

The MAPK pathway is one of the most heavily studied pathways in cancer. The MAPK pathway is an important regulator of many processes that are critical to the malignant phenotype, and a variety of genetic alterations that activate the pathway have been detected in many different kinds of cancer. As a result, the development of inhibitors against the pathway has been an active area of investigati...

Epigenetic approaches to overcoming chemotherapy resistance.

Overcoming antiangiogenic resistance.

The success of drugs targeting angiogenesis is tempered by the transient duration of disease control and modest survival improvement. The very hypoxic stress produced by successful therapy may lead to upregulation of multiple pathways that promote angiogenesis and invasive behavior. Overcoming this evasive resistance may further improve outcome.